No actress auditioned for the part of Spiderman's traditional love interest, Mary Jane Watson. Gwen Stacy was the coveted role that all actresses auditioned for. THR reported that:
"Mary Jane will not appear in the first movie, so a Gwen
story line could provide and extra dose of gravitas, depending on how closely
the studio and filmmakers hew to Marvel Comics lore."
Read on.
So Emma Stone's Gwen Stacy is the primary love interest. THR also stated:
"In the
comics, Gwen was Parker’s first love but died in a fight against the Green
Goblin. The studio is not expected to have Green Goblin as the villain in order
to distance itself from the previous trilogy (Philip Seymour Hoffman is on the
shortlist for the new villain role), but it doesn’t preclude a similar story
line to pack dramatic punch."
